The Mamata Medical College was started in the year 1998 in the heart of Khammam municipal corporation limits abutting state highway and well connected by road, rail and nearest air ports are Hyderabad and Amravati (Vijayawada) which are 180 and 130 kms away. The location of this campus with college, Hospital, Hostels and other facilities are situated on 17.25 latitude and 80.14 longitude and 1120mts above the  sea level and enjoys salubrious and pollution free pleasant weather throughout the year.

The campus is spread over 40 acres with a total built up area of 90,935sq.mtrs which includes the college building and hospital .The college building has total of 4 floors and includes individual departments, 4 gallery lecture halls, medical education unit, separate common rooms for boys and girls. The campus also includes undergraduate, internees, post graduate, NRI hostels with mess for boys and girls. The campus also has bio waste management plant, water shedding units and Sewage Treatment Plant (STP). There is an air cooled auditorium, Audio visual hall and open air theatre for various functions and gatherings. Campus also has residential quarters for staff to accommodate 96 members and play grounds for various indoor and outdoor sports and games and an ultra modern Gym.

The central library with centrally air conditioning has a built up area of 8,840 sq,ft. with a 300 seating capacity in main library, 30 for staff,70 for PG students,30 in Journal section and 58 in  e-library was inaugurated in 2008.. It has reading rooms for staff and students and digital library with 48 portals. The library is equipped with over 17,672 books which includes 13,106 text books and4566 reference books and subscribes 120 journals with 80 national and 40 international journals annually and back volumes 15480 issues from1995. Library also includes 1433 dissertations and 664 CDs. The digital library has access to nearly 619 online journals through NTRMEDNET, INFLIBNET, and HEINET. Photo copying, book binding and lamination facilities are provided in the library.  Internet facilities are provided to all departments for staff and students.Library further symbolizes MES initiative and relentless pursuit in providing excellent academic exposure and related benchmarking to our students and faculty. The college maintains high standards in teaching and evaluation processes as evinced by the high pass percentage with a substantial number of students securing gold medals, distinctions and first classes in the university examinations. This is a testimony to the efforts of the dedicated faculty who will continue to strive for higher peaks. The achievements of the institution include bagging of 10 gold medals by UG and PG students in the examinations conducted by the Dr. Kaloji Narayana University of Health Sciences, Warangal, Telangana during every academic year. To further the academics of students, college conducts Study Hour schedules for I & II MBBS students and progress is monitored by adopting the Mentor System. The college also obtains feedback from both faculty and students and stake holders. College organizes yearly training program for faculty in medical education and evaluation and training programs on basic research.  Every year, college is offering tuition fee subsidy to 20 staff children and deserving economically backward students.  College has instituted a yearly Cash Prize of Rs. 75,000/- to the “Best Out Going Student” of the college.